Domenici Hall Cores and Investigator Services

Domenici Hall's cutting-edge and centralized research cores provide an array of services dedicated to furthering brain research.

The cores are open to all scientists interested in using neuroimaging tools to discover the mechanisms of brain functions in health and disease. We welcome brain and behavioral health scientists from UNM and beyond to join our exciting international research environment.

Imaging Cores
Animal Cores
Pre-Clinical Assessment Animal Magnetic Resonance Imaging
Electron Parametric Resonance (EPR) Spectroscopy Clinical Assessment
Human Image Analysis Clinical Neuropsychology and Stimulation


Clinical Neuropsychology and Stimulation

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The Clinical Core is a fundamental component of the Center for Brain Recover and Repair (CBRR) established by an NIGMS Center for Biomedical Research Excellence (CoBRE) grant.

The Clinical Core is located in Domenici Hall on UNM’s North Campus strategically-located in the very “heart” of the UNM neuroscience research community. This core provides facilities, resources and expertise to support clinical neuroscience investigations.

It includes a neuropsychological assessment library, clinical research assessment rooms, cutting-edge technology (e.g., tDCS, EEG), well-trained research assistants/psychometrists, as well as training to support the design and implementation of clinical neuroscience investigations.

The Clinical Core provides a convenient, participant-friendly point-of-service, adjacent to basic research, neuroimaging, and clinical medicine facilities.

Facilities and Equipment

  • Neuropsychological Test Library is a state-of- the-science collection of neuropsychological instruments housed in Domenicic Hall to be utilized in Center research projects focused on brain recovery and repair.
  • EEG The actiCHamp and PyCorder 64-channel Brain Vision EEG system is a revolutionary development that integrates high-end components for electrophysiological (EEG/ERP, ExG, BCI, etc.) research in one easy to use, highly versatile, and affordable system.
  • Transcranial direct current stimulation (tDCS) state-of the-art tDCS equipment to conduct studies of neurostimulation, including a DC-stimulator, a CE-certified medical device for conducting non-invasive transcranial direct stimulation (tDCS), alternating (tACS) or random noise (t(RNS) current stimulation on people.
  • Functional Near-Infrared Spectroscopy (fNIR or fNIRS) FNIR Optical Brain Imaging Station that monitors and analyzes neural activity and hemodynamic response in the prefrontal cortex.  
Hourly Service Rates
 

UNM-Affiliated Research

Non-UNM or Industry Research

Room Use $15.00 $30.00
Room and Equipment $30.00 $45.00
Technician-Assisted Room and Equipment $52.00 $77.00
Consultation Free for UNM Researchers $50.00


Pre-Clinical Assessment

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The Preclinical Core Facility houses resources for automated behavioral testing, including touchscreen inputs and gait analysis tools.

The resources at the Preclinical Core include automated animal tracking systems, learning and memory tasks, motor and gait analysis systems, in-vivo single and multiphoton imaging, optogentics, in-vivo electrophysiology, histology, and 3D and 4D image analysis.

Facilities and Equipment

  • Motion Tracking
  • Motor and gait analysis
  • State-of-the-art surgical suites
  • Awake and behaving in-vivo imaging
  • In-vivo electrophysiology
  • Optogenetics
  • Histology
  • Imaris 3D and 4D image analysis software
Service Rates

Service

Details

UNM-Affiliated Research

Non-UNM or Industry Research

Training and Consultations All users must be trained on the equipment prior to use of the facilities. The Preclinical Core Staff can also provide consultations for experimental design and troubleshooting. $51.50/hour $78.00/hour
Motion Tracking Includes: open field, novel object recognition, Y-maze, zero maze, and Morris water maze. $15.50/hour (service) $25.00/hour (service)
$7.50/hour (usage) $12.00/hour (usage)
Rotarod Simple and effective way to measure motor learning. $15.50/hour (service) $25.00/hour (service)
$7.50/hour (usage) $12.00/hour (usage)
Catwalk A sofisticated and high-through put system to measure gate and motor performance in mice or rats. $20.00/hour (service) $30.00/hour (service)
$10.00/hour (usage) $15.00/hour (usage)
In-vivo electrophysiology, optogenetics and in-vivo mini-scopes Highly effective ways to monitor and manipulate neuronal activity while the animal is awake and behaving $25.00/hour (service) $38.00/hour (service)
$12.50/hour usage) $20.00/hour (usage)
CLARITY A innovative way to optically clear tissue to image large flourescent 3 dimentsional structures. $300.00 for the first sample, additional samples $200.00 each (service) $450.00 for the first sample, additional samples $300.00 (service)
$10.00 for the first sample, additional samples $5.00 each (usage) $15.00 for the first sample, additional samples $7.50.00 each (usage)
Imaris 3D and 4D image analysis software Highly powerful analysis software capable of automated 3D and 4D quanitfication. $15.50/hour (service) $25.00/hour (service)
$7.50/hour (usage) $12.00/hour (usage)


Animal Magnetic Resonance Imaging

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The MRI Core includes an actively-shielded 7.0T MRI scanner (Bruker Biospin) dedicated exclusively to animal imaging.

The MRI Core is capable of several types of imaging:

  • T1
  • T2
  • T2*
  • Perfusion Weighted Imaging (PWI)
  • Diffusion Weighted Imaging (DWI)
  • Diffusion Tensor Imaging (DTI)

Capabilities

  • High field MRI performed with a quadrature surface receive coil provides excellent resolution in vivo.
  • T2-weighted, T1-weighted and proton density imaging sequences can be performed to identify lesions or to monitor administered contrast agents.
  • The MRI Core can perform Diffusion Weighted Imaging (DWI) acquisitions and determine Apparent Diffusion Coefficient (ADC) maps. Diffusion Tensor Imaging (DTI) protocols have recently been implemented in the 7.0T scanner.
  • Blood Brain Barrier (BBB) Permeability Measurements

Equipment

The MRI Core houses a 7.0T 40 cm bore MR scanner for both structural and functional MRI in animal models. This actively shielded Bruker NMRI system is equipped with two distinct water-cooled gradient sets:

  • A large-bore gradient set (ID 26 cm) with a maximum gradient strength of 10 Gauss/cm
  • A small-bore gradient set (ID 12 cm) which has a 50 Gauss/cm maximum gradient strength

Both gradient sets can tolerate the high duty cycles required for fast imaging techniques like Echo Planar Imaging (EPI).

The NMRI system is equipped with Bruker AVANCE I electronics located in a separate room adjacent to the magnet. The AVANCE system consists of waveform generation, receiver, and digitizer units, and a 64-bit CPU for data pre-processing.

Proton Coils

The MRI can provide access to a variety of coils. All coils are compatible with fast imaging methods (EPI, DTI, and fMRI).

Data Processing Capabilities

A dedicated workstation is available for data transfer and offline data processing.
  • MATLAB (Mathworks Inc.)
  • ImageJ (NIH, Bethesda, MD)
  • 1 Gbps ethernet network in-building allows offline and offsite analysis of MR data

Animal Handling

The MRI Core is well-equipped for animal handling.  

Hourly Service Rates
 

UNM-Affiliated Research

Non-UNM or Industry Research

MRI Core Resource Use $150.00 $300.00


Electron Paramagnetic Resonance (EPR) Spectroscopy

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EPR is a versatile, nondestructive analytical technique which can be used for a variety of applications including: oxidation and reduction processes, biradicals and triplet state molecules, reaction kinetics. The EPR Core is where researchers can make unique contributions to the measurement and understanding of ROS associated with neurological disorders using in vivo and in vitro models. 

This core highlights brain injury and CNS pathophysiology EPR spectroscopy and advanced imaging techniques.

 Capabilities

Researchers can perform in vitro or in vivo EPR experiments including:
  • Direct measurements of free radicals and oxidative stress in small samples
  • Measurements of pO2 (EPR oximetry) in vitro and in vivo using stable spin probes whose linewidths are influenced by O2 concentration.
  • Measurements of microenvironments in which a spin label has been introduced.

Equipment

The lab is equipped with two EPR spectrometers, an X-band for in vitro studies and an L-band for in vivo studies and can provide access to three resonators depending on the nature of the study.

The Bruker gradient system can produce field gradients of more than 55 G/cm (0.55 T m-1) giving sub-millimeter resolution.

 

EPR Core Resource

Study Application

Spectrometers

Bruker EleXsys E500 X-band equipped with a standard TE102 resonator and variable temperature control system. 9.5 GHz.

In vitro measurement of small samples

Bruker EleXsys E-540 L-band. 1.0 GHz, low frequency.

In vivo imaging of free radical formations in small animals

Resonators

Imaging Resonator

Mouse or rat brain

34mm and 36mm internal diameter birdcage resonators

Small animals

An external loop resonator

Localized measurement of small animals

 

Hourly Service Rates
 

UNM-Affiliated Research

Non-UNM or Industry Research

EPR Core Access $40.00 Not available
EPR Core Acess with Staff Scientist Support $80.00 $125.0